Jennifer Ton, MSInstructor and Program Director of the MBS in Bioprocessing
Microbiology and Cell Banking and Strain Metabolism, Strain, Fermentation and Purification Development, Screening and In-Process Assay Development, Process Engineering and Control, Laboratory Safety and Operation Flow Optimization, Biocatalyst Development and Biocatalysis Process Development, Quality by Design / Design of Experiment / Risk Assessment, Root Cause Analysis / CAPA / Continuous Improvement, Stability Program Management, Supply Chain Strategy, CMO Identification / Technology Transfer / GMP Manufacturing Oversight, Custom Equipment Design / Integration of Disposables, BioBusiness Strategy, Development and Marketing, CMC Regulatory Filings and Support, Team Leadership and Technical Talent Development
Jennifer Ton is an Instructor and the Program Director for the MBS in Bioprocessing at KGI. She has over 25 years of experience in strain and bioprocess development, scale up and manufacturing support. She directed development of processes to produce 10 biologics, as well as fifteen fermentation and biotransformation reactions for the production of natural and unnatural amino acids and functional chemicals. She led scale up and technology transfer of over fifteen processes to 10 different CMO's, globally, at scales ranging from 20L to 500KL. She supported two commercial products that each exceeded a $Billion per year in revenue, one in the food industry and the other in Pharma.
She is the Founder and President of BioRox, Inc., a biotechnology development and consulting company providing services to the biopharma and biotech industries. Previously she was with Allergan in Irvine, CA, as Sr. Director, Biologics Development Process Sciences where she led a team of up to 60 scientists and engineers in developing the manufacturing processes for biologics in clinical development, as well as providing ongoing technical support for Botox® commercial manufacturing. She was responsible for the process development activities from gene and expression vector design through to the final drug product vial, as well as the stability program for all biologics in clinical development. Prior to that, she was a biotechnology consultant in Palatine, IL supporting several clients in the biosynthesis of high value chemicals. Jennifer held positions of leadership in microbiology and bioprocess development at Albany Molecular Research, Inc.; Great Lakes Chemical Co.; Monsanto in NSC Technologies and The NutraSweet Company; and G.D. Searle. Jennifer has a B.S. in Bacteriology from the University of Wisconsin-Madison and an M.S. in Biology (Biotechnology Core) from the Illinois Institute of Technology in Chicago. Her thesis combined molecular biology and biochemical engineering resulting in her first patent. She is inventor on 5 patents and over 20 patent applications in progress.
This course will provide students with hands-on experience setting up, operating and analyzing fermentations.
Bioprocessing is a technology used in a variety of industries. This course will provide an overview of various industrial uses of microbial bioprocessing. The course will present bioprocessing in industries ranging from the food and pharmaceutical industries to the chemical and green-tech industries. The course is designed to teach students the basic fundamentals of a bioprocess and what they need to know about the similarities and the unique aspects of bioprocessing in each industry covered.
This course is open to MBS, MS, PPC and PPM students that are interested in getting hands-on bioprocessing research experience.
This course focuses on issues specific to operations in biotechnology, including high variability in process operations, the need for very high supply reliability (no patient goes without) as well as long cycle times for biotech manufacturing.
- Considerations When Implementing Single-Use Components into a Bioprocess. Jennifer Ton, Presented at Keck Graduate Institute, Claremont, CA, 2013.
- Establishing Process Design Space from Concept to Implementation. A Case Study, Derek Chan, Hui Xiang, Jennifer Ton, and Ronald Bates, Presented at IBC's 18th Annual Process Validation and Continuous Verification, Huntington Beach, California, 2013.
- From Process Development to Clinical Material manufacture - Implementation of QbD Concept and Strategy to Smooth the Technology Transfer. Tsu-shun Lee, Edward Crabbe, Patrick Haley, Ji Zheng, Sue Marrichi, Jennifer Ton. Presented at IBC's 6th International Technology Transfer for Biopharmaceuticals, Bellevue, Washington, 2011.
- Implementation of Single-Use Technology in Laboratory- and Manufacturing-Scale Downstream Processing. Hui Xiang, Derek Chan, Jennifer Ton, and Ronald Bates, Presented at BPI Annual Conference, Long Beach, California, 2011.
- Application of QbD and PAT Methods to an E. coli Protein Purification Process Development Project. Ji Zheng, Phillip Nguyen, David Didio, Johnney Wu, Pam Cifra, Jennifer Ton, and Ronald Bates, Presented at BPI Annual Conference, Long Beach, California, 2011.
- Prevention of Freeze- and Thaw-Induced Protein Aggregation and Optimization of a Drug Substance Matrix. Hui Xiang, Derek Chan, Jennifer Ton, and Ronald Bates, Presented at BPI Annual Conference, Long Beach, California, 2011.
- Application of Risk Assessment and Design Space Concept to Early Phase Fermentation Process Development of Recombinant Protein Production. Edward Crabbe, Tsu-shun Lee, Jonathan Huang, Chris Agacite, Karolyn Tran, Kydah Dang, Hemant Patel, and Jennifer Ton. Presented at 241st ACS National Meeting and Exposition, Anaheim, California, March 2011.
- Development and Application of an E.coli Protein Purification Platform. Ji Zheng, Phillip Nguyen, David Didio, Johnney Wu, Pam Cifra, Mandana Jafarinejad, Jennifer Ton, and Ronald Bates, Presented at 239th ACS National Meeting, San Francisco, California, 2010.
- Achieving High Efficiency Biopharmaceutical Manufacturing Process Development by Implementation of Quality by Design (QbD) and Process Development (PD) "Leap." Tsu-shun Lee, Edward Crabbe, Patrick Haley, Ji Zheng, Jennifer Ton. Presented at Spring 2010 ACS National Meeting and Exposition, San Francisco, California, 2010.
- Prokaryote Platform Process: Perils, Pitfalls, Payback. Jennifer Ton, Hemant Patel, Hui Xiang, and Ronald Bates, Presented at IBC's Non-Antibody Protein Therapeutics Development and Production, Carlsbad, California, 2009.
- Developing an Anaerobic System at MicroScale: Neurotoxin Process Development. Patel, H.; Ton, J.; Ie, E.; Kehrer, R.; Huang, J.; Bangi, K.; Ahmad, W., Presented at Society for Industrial Microbiology Annual Meeting, 2007, Denver, Colorado, Presentation S131.
- Synthetic Biocatalysis: A Practical Tool for Drug Discovery, Development, and Production. Michels, Peter C.; Khmelnitsky, Yuri L.; Rich, Joseph O.; Pantaleone, David P.; Ton, Jennifer L., Presented at NERM 2003, Union College, Schenectady, New York, 2003.
- Great Lakes Fine Chemicals - Focusing on Technology. Ton, J.; Altman, M., Presented at Informex 2001 Exhibitor Showcase, New Orleans, Louisiana, 2001.
- d-Phenylalanine Biosynthesis Using Escherichia coli: Creation of a New Metabolic Pathway. Taylor, P.; Grinter, N.; McCarthy, S.; Pantaleone, D.; Ton, J.; Yoshida, R.; Fotheringham, I., in Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals, B. C. Saha, D. C. Demirjian, eds., ACS Symposium Series No. 776, Am. Chem. Soc. Press, Washington, D.C., 2001, Chapter 5, pp. 65-75.
- Biocatalytic Preparation of d-Amino Acids. Pantaleone, D.; Taylor, P.; Dukes, T.; Vogler, K.; Ton, J.; Beacom, D.; McCarthy, S.; Meincke, B.; Behrendt, L.; Senkpeil, R.; Fotheringham, I. in Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals, B. C. Saha, D. C. Demirjian, eds., ACS Symposium Series No. 776, Am. Chem. Soc. Press, Washington, D.C., 2001, Chapter 11, pp. 165-175.
- Unnatural Amino Acids by Transaminase Reactions. Senkpeil, R.; Taylor, P.; Pantaleone, D.; Fotheringham, I.; Ton, J.; McCarthy, S.; Ager, D., in Peptides, S. Bajusz and F. Hudecz, eds., Akadémiai Kiadó, Budapest, Hungary, 1999, 136-137.
- Production of d-Amino Acids Using Two d-Amino Acid Aminotransferases from Bacillus. Senkpeil, R.; Taylor, P.; Grinter, N.; Pantaleone, D.; Ton, J.; McCarthy, S.; Dukes, T., Presented at 16th American Peptide Symposium, Minneapolis, Minnesota, 1999, P444.
- d-Phenylalanine Biosynthesis Using Escherichia coli: Creation of a New Metabolic Pathway. Taylor, P.; Grinter, N.; McCarthy, S.; Pantaleone, D.; Ton, J.; Yoshida, R.; Fotheringham, I. Presented at ACS National Meeting, Anaheim, California, 1999, BIOT-P174.
- Biocatalytic Preparation of d-Amino Acids, Pantaleone, D.; Taylor, P.; Dukes, T.; Vogler, K.; Ton, J.; Beacom, D.; McCarthy, S.; Meincke, B.; Behrendt, L.; Senkpeil, R.; Fotheringham, I. Presented at ACS National Meeting, Anaheim, California, 1999, BIOT-P148.
- "Biocatalytic Routes for the Production of Unnatural Amino Acids. Pantaleone, D.; Taylor, P.; Senkpeil, R.; Ton, J.; McCarthy, S.; Beacom, D.; Fotheringham, I. Presented at Advances in Industrial Biocatalysis, InBio Europe '98, Amsterdam, The Netherlands,1998.
- An Inducible Chromosomal Expression Vector Based on the Bacteriophage Mu. Yoshida, R.; Fischbein, S.; Kootstra, A.; Patel, H.; Ton, J.; Zhou, W.; Weinberg, R. Presented at SIM Annual Meeting 1998.
- Preparation of d-Aspartic Acid Using l-Aspartate-1-Decarboxylase. Pantaleone, D.; Fotheringham, I.; Ton, J. Presented at ACS National Meeting, San Francisco, California, 1997, BIOT-P196.
- Biosynthesis of Unnatural Amino Acids using Heterologous Enzymatic Activities in Escherichia coli. Dailey, J.; Grinter, N.; Nelson, R.; Pantaleone, D.; Senkpeil, R.; Taylor, P.; Ton, J.; Yoshida, R.; Fotheringham, I. Presented at the 24th Symposium of the European Peptide Society, Edinburgh, Scotland, 1996.
- Purification and Characterization of Dehydrogenases from Gluconobacter oxydans. Senkpeil, R.; Pantaleone, D.; Nelson, R.; Ton, J. Presented at American Society of Biochemistry and Molecular Biology National Meeting, San Francisco, California,1995.
- Jennifer Ton, Ronald Bates, Ji Zheng, Phillip Nguyen, and Timothy O'Neill. Stabilization of Therapeutic Agents to Facilitate Administration, U.S. Patent WO/2011/075500, 2011.
- Jennifer Ton, Hemant Patel, Ronald Bates, and Wajdie Ahmad. Process and System for Obtaining Botulinum Neurotoxin, U.S. Patent WO/2011/008713, 2011; U.S. Patent 8,129,139 B2 2012; 8,324,349 B2 2012; 8,357,541 B2, 2013.
- David P. Pantaleone, Ian G. Fotheringham, and Jennifer L. Ton, 1998. Process and Composition for Preparing d-Aspartic Acid. U.S. Patent 5,834,259.
- Ian G. Fotheringham, Paul P. Taylor, and Jennifer L. Ton, 1998. Production of Enantiomerically Pure d-Amino Acids by Direct Fermentative Means. U.S. Patent 5,728,555.
- Ian Fotheringham, Jennifer Ton, and Chris Higgins, 1994. Materials and Methods for Hypersecretion of Amino Acids. U.S. Patent 5,354,672.
- Over twenty additional process and use patent applications in progress.
|Jennifer Ton, MS|
|Location:||Building 535, Room 149B|