Larry Grill, PhDResearch Professor and Director of Amgen Bioprocessing Center
Animal and Human Vaccines, Vaccine Production, FDA Regulatory Processes, Cancer Therapeutic Vaccines, Biopharmaceuticals
Professor Grill is the Director of the Amgen Bioprocessing Center at KGI. In this role, he leads both educational programs and research efforts involving students, faculty, and corporate sponsors. In addition to teaching courses at the Keck Graduate Institute, he also teaches undergraduates at the Keck Science Department of the Claremont Colleges. With ongoing research programs in vaccine development and disease diagnostics, collaborations with the University of Botswana, the Botswana Vaccine Institute, and the International Livestock Research Institute in Kenya, aim to address health care delivery in developing countries. This includes the development of novel technology for the detection of infectious diseases, as well as the development and production of low cost vaccines for developing countries. Dr. Grill was one of two founders who started Large Scale Biology Corporation (LSBC) in 1987, which became a publicly-held company in 2000. The biotechnology company made therapeutic drugs, pharmaceuticals and vaccines using a unique plant viral gene expression technology. In the development of these drugs, Dr. Grill developed innovative bioprocessing technology to produce and purify the molecules expressed in plants. They had successful animal and human clinical trials, and were able to produce patient-specific vaccines as a therapeutic treatment for non-Hodgkin's lymphoma cancer patients. Dr. Grill received his Ph.D. from the University of California in Riverside in 1979. He has published over 25 scientific papers and is an inventor on more than 30 issued US and world patents.
This course is designed to provide an understanding of how pharmaceutical companies discover, develop, and bring drugs and biopharmaceuticals to market. This course will focus on the development of traditional and biological drugs. The course will follow the process of drug development, taking the drug substance through the process of becoming a drug product, and then into clinical development and commercialization.
This course will provide students with a background of the scientific basis of some key aspects of biotechnology based drug, biologic and vaccine design, discovery and development process. Students will learn about therapeutic and vaccine targets, and how the drugs and vaccines are designed, tested and produced.
- Grill LK, Palmer KE, Pogue GP. "Use of plant viruses for production of plant-derived vaccines". Critical Reviews in Plant Sciences 2005;24(4):309-323
- Grill LK. "Production of Pharmaceutical Proteins Using Viral Vectors". In: Christou P, Klee H, editors. Handbook of Plant Biotechnology, Vol. 2. John Wiley & Sons, Ltd.; 2004. p. 781-789.
- Grill LK, Lindbo J, Pogue GP, Turpen TH. "Viral vector expression of foreign proteins in plants". In: Hood EE, Howard JA, editors. Plants as Factories for Protein Production. Kluwer Academic Publishers, The Netherlands; 2002. p. 3-16.
- McCormick AA, Kumagai MH, Hanley K, Turpen TH, Hakim I, Grill LK, Tuse D, Levy S, Levy R. "Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants". Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):703-708.
- Mohagheghpour N, Waleh N, Garger SJ, Dousman L, Grill LK, Tusé D. "Synthetic melanin suppresses production of proinflammatory cytokines". Cellular Immunology 2000;199(1):25-36.
- DellaCioppa G, Grill LK. "Production of novel compounds in higher plants by transfection with RNA viral vectors". IN: Annals of the New York Academy of Sciences, Vol. 792 Engineering Plants for Commercial Products and Applications Ed. G.B. Collins and R.J. Shepherd 1996;792:57-61
- Kumagai MH, Donson J, DellaCioppa G, Harvey D, Hanley K, Grill LK. "Cytoplasmic Inhibition of Carotenoid Biosynthesis with Virus-Derived Rna". Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1679-1683.
- Turpen TH, Reinl SJ, Charoenvit Y, Hoffman SL, Fallarme V, Grill LK. "Malarial Epitopes Expressed on the Surface of Recombinant Tobacco Mosaic-Virus". Bio-Technology 1995;13(1):53-57.
- Kumagai MH, Sverlow GG, DellaCioppa G, Grill LK. "Conversion of Starch to Ethanol in A Recombinant Saccharomyces-Cerevisiae Strain Expressing Rice Alpha-Amylase from A Novel Pichia-Pastoris Alcohol Oxidase Promoter". Bio-Technology 1993;11(5):606-610.
- Kumagai MH, Turpen TH, Weinzettl N, DellaCioppa G, Turpen AM, Donson J, Hilf ME, Grantham GL, Dawson WO, Chow TP, et al. "Rapid, High-Level Expression of Biologically-Active Alpha-Trichosanthin in Transfected Plants by An Rna Viral Vector". Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):427-430
Dr. Grill's research focuses on the development of plant viruses as expression vectors to produce human and animal therapeutics and vaccines. He is an inventor on more than 30 issued US and foreign patents while developing of the capabilities of this technology.After the technology was working well, the company has progressed from small quantity production in the laboratory to large scale production at its Kentucky facility. Several other production facilities have been built using this initial design. The success of the company's non-Hodgkin's lymphoma clinical trials led to Bayer Healthcare purchasing the technology to advance to the next stage of drug development.
|Larry Grill, PhD|
|Location:||Building 517, Room 225|