Dr. Michael S. Levine
Illuminating Striatal Connections in Huntington's Disease: Inputs and Interneurons
Dr. Levine received his B.A. in Psychology from Queens College in New York City, and his Ph.D. in Physiological Psychology from the University of Rochester in New York. He obtained a postdoctoral position at UCLA, and then joined the faculty at UCLA in the Department of Psychiatry and Biobehavioral Sciences, where he currently holds the Gail Patrick Chair in Brain Research. His research interests involve the cellular physiological mechanisms in neurodegenerative and developmental disorders and diseases and have been directed toward understanding the functions of the nuclei of the basal ganglia and its associated structures like the cerebral cortex. His laboratory investigates how these neural areas function and how this function is altered in models of diseases. One disease studied in his laboratory for the past 15 years is Huntington's disease. His research group has examined different genetic mouse models and evaluated electrophysiological and morphological abnormalities in the cortex and the basal ganglia as the phenotype develops and proceeds. Dr. Levine's group was one of the first laboratories to describe electrophysiological alterations in striatum and cortex in multiple mouse models.