James D. Sterling,
PhD
Associate Professor, Director of the Team Masters Program Areas of Expertise:
- Bioengineering
- Electrowetting
- Microfluidics
Dr. Sterling received degrees in Mechanical Engineering with a BS from Texas A&M University and MS and Ph.D. degrees from Caltech. At KGI, Dr. Sterling has led the development of the bioengineering curriculum, which includes components of engineering science, design practice, and biotechnological applications. He teaches elements of engineering design, systems modeling, biotransport, microfluidics and microfabrication, flow cytometry, control theory, and the Systems Engineering approach to product development.
Dr. Sterling co-directs the Microfluidics Research Laboratory at KGI with Dr. Ali Nadim; their current research is aimed at the development of miniaturized systems for biomolecular analysis and manipulation. Miniaturization is critical to the development of high-throughput biomolecular diagnostics and biosensors as it facilitates rapid processing and automation. Interest in miniaturization of these systems has led to the formation of a number of companies and a plethora of research activity around the world involving microfluidic “biochip” development. Biochips are being developed for medical applications in drug discovery and medical treatment (to identify biomolecular targets and test new drugs and treatments) as well as medical diagnostics (to identify genetic characteristics that either predispose an individual to a particular disease or to the utilization of a particular drug.)
Last updated 12.14.2006
|
| Y. Daneshbod, J. D. Sterling, and A. Nadim, (2005) Determination of Kinetic Rates in Reactions Undergoing Electrophoresis, in preparation.
J. D. Sterling, (2004) Laboratory Automation Curriculum at Keck Graduate Institute, JALA, 9, 331-335.
J. D. Sterling, C. Cooney, P. Qu and A. Nadim, Nucleic Acid Amplificaiton Using Electrowetting Droplet Control, 4th International Discussion Meeting on Electrowetting, Blaubeuren, Germany, September 7, 2004.
J. Dai, J. D. Sterling and A. Nadim, (2004) Numerical Simulation of Air Bubbles Rising in Water Using an Axisymmetric VOF Method, in Computational Methods in Multiphase Flow II, A. A. Mammoli and C. A. Brebbia, Editors, pp. 343-351, WIT Press, Southampton. J.D. Sterling, R. Chen, J. Dai, E. Fabrizio and A Nadim, (2003) Sample Handling Using Contact Line Driven Flow, Lab Automation 2003, Palm Springs, CA.
J.D. Sterling, E. Fabrizio, A. Nadim, (2003) Sequence Dependent Mobility of Short Oligonucleotides in Free Solution Electrophoresis, Summer Bioengineering Conference, June 2003. E. Fabrizio, A. Nadim, J.D. Sterling, J. Free Solution Capillary Electrophoresis of DNA in the Presence of Electro-osmotic Flow with Uncoated Microfluidic Chips, BECON 2002, Bioengineering Consortium poster.
|
12.14.2006
|
|
Current research topics include efforts to develop:
Chip-based capillary electrophoresis for identification and separation of biomolecules in free-solution under
- Electric fields that are higher than commonly used in CE or gel-based systems.
- Improved methods for delivering and characterizing the DNA probes and targets in gene expression microarray systems: this includes experimental characterization of surface molecular morphology using atomic force microscopy and neutron scattering as well as microarrayer pin design studies utilizing computational fluid dynamic simulations
- Electrowetting-based fluidic control systems designed to move samples via control of local micro-electrode potential.
|
12.14.2006
|
|
Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like.
U.S. Patent Application 60/333,621. |
|
|
 |
 Contact InformationJames D. Sterling
909/607-9253
Jim_Sterling@kgi.edu
ResourcesJames Sterling's faculty Web site
James Sterling's research website
|
