Evaluation of Pre-filled Plastic Syringes as the Primary Container for Therapeutic Proteins
Team Masters Projects 2006-07
May 02,
2007
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TMP Sponsor: Amgen Company Advisors:
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| KGI Team Members: |
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Adam Gross
Tran Pham
Amy Jarvis
Jonathan Chen
Rachel Howden
Kathleen Wang
Nina Bordeaux
Gena Urowsky
Jeffrey Rubinstein
Sunitha Jagannathan
Rajesh Chitta |
| KGI Faculty Advisors: |
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Deb Chakravarti
Nancy Lape |
This joint Keck Graduate Institute-Harvey Mudd College project was continued from last year. The main goal was to evaluate the switch from glass to plastic pre-filled syringes. To support the assessment, analytical biochemistry experimental methods were developed to minimize oxygen permeation in plastic syringes. The team also tested various secondary packaging and oxygen absorber systems. The experimental results were strengthened by developing and refining a mathematical model of oxygen permeation through syringe and secondary packages. The technical evaluation was complemented by market research and financial models. Patent research to investigate licensing opportunities and potential infringement are completed. |
