Nadim, A. "Modeling of Mass-Transfer Limitation in Bio-Molecular Assays" Interdisciplinary Transport Phenomena: Ann. N.Y. Acad. Sci. 1161: 34-43 (2009)

Doebler, R.W.; Erwin,  B.; Hickerson, A.; Irvine, B.; Woyski,  D.; Nadim, A.; Sterling, J.D. "Continuous-Flow, Rapid Lysis Devices for Biodefense Nucleic Acid Diagnostic Systems" J. Assoc. Lab. Automation 14: 114-125 (2009)

Nadim, A. "Interface Capturing Schemes for Free-Surface Flows" in Encyclopedia of Microfluidics and Nanofluidics Part 9: 841-849, D. Li (Ed.), ISBN 978-0-387-32468-5, Springer (2008)

Nadim, A.; Sterling, J.D. "Transport of Droplets by Acoustics" in Encyclopedia of Microfluidics and Nanofluidics Part 20: 2096-2104, D. Li (Ed.), ISBN 978-0-387-32468-5, Springer (2008)

Chickarmane, V.; Ray, A.;  Sauro, H.M.; Nadim, A. "A Model for p53 Dynamics Triggered by DNA Damage" SIAM J. Appl. Dyn. Syst. 6: 61-78 (2007)

Daneshbod, Y.; Sterling, J.D.; Nadim, A. "Moment Analysis of Near-Equilibrium Binding Interactions during Electrophoresis" Phys. Rev. E, 76: 051922:13 (2007). (Selected for inclusion in the December 1, 2007 issue of Virtual Journal of Biological Physics Research.)

Wong, C.-J.; Nadim, A. "An Embedding Method for Simulation of Immobilized Enzyme Kinetics and Transport in Sessile Hydrogel Drops" (PAMM: ISSN 1617-7061) Proc. Appl. Math. Mech. 7(1): 2100015-2100016 (2007)

Cooney, C.G.; Chen, C.Y.; Emerling, M.R.; Nadim, A.; Sterling, J.D. "Electrowetting Droplet Microfluidics on a Single Planar Surface" Microfluidics and Nanofluidics 2: 435-446 (2006)

Nadim, A.; Borhan, A. "Confined Motion of a Long Bubble through a Power-Law Fluid" AMRX Applied Mathematics Research eXpress 36283: (2006)

Olufsen, M.S.; Nadim, A. "On Deriving Lumped Models for Blood Flow and Pressure in the Systemic Arteries" Mathematical Biosciences and Engineering 1: 61-80 (2004)

Ravoux, J.F.; Nadim, A.; Haj-Hariri, H. "An Embedding Method for Bluff Body Flows: Interaction of Two Side-by-Side Cylinder Wakes" Theoretical and Computational Fluid Dynamics 16: 433- 466 (2003)

Fabrizio, E.F.; Nadim, A.; Sterling, J.D. "Resolution of Multiple ssDNA Structures in Free Solution Electrophoresis" Anal. Chem. 75: 5012-5021 (2003)

Ravoux, J.F.; Provansal, M.; Nadim, A.; Shouveiler, L. "Strouhal-Reynolds Number Relationship for Bluff-Body Flows Numerically Simulated by an Artificial Boundary Method" Phys. Rev. E. 68: 055702(R) (2003)

Olufsen, M.S.; Nadim, A.; Lipsitz, L.A. "Dynamics of Cerebral Blood Flow Regulation Explained Using a Lumped Parameter Model" Am. J. Physiology 282: R611-R622 (2002)

Gupta, N.R.; Nadim, A.; Haj-Hariri, H.; Borhan, A. "A Numerical Study of the Effect of Insoluble Surfactants on the Stability of a Viscous Drop Translating in a Hele-Shaw Cell" J. Colloid Interface Sci. 252: 236-248 (2002)

Khismatullin, D.B.; Nadim, A. "Radial Oscillations of Encapsulated Microbubbles in Viscoelastic Liquids" Phys. Fluids 14: 3534-3557 (2002)

Khismatullin, D.B.; Nadim, A. "Shape Oscillations of a Viscoelastic Drop" Phys. Rev. 63: 061508 (2001)

Harkin, A.; Kaper, T.J.; Nadim, A. "Coupled Pulsation and Translation of Two Gas Bubbles in a Liquid" J. Fluid Mech. 445: 377-411 (2001)

Rush, B.M.; Nadim, A. "The Shape Oscillations of a Two-Dimensional Drop Including Viscous Effects" Engineering Analysis with Boundary Elements 24: 43-51 (2000)

Olufsen, M.S.; Peskin, C.S.; Kim, W.Y.; Pedersen, E.M.; Nadim, A.; Larsen, J. "Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow Conditions" Annal. Biomed. Engr. 28:1281­­­-1299 (2000)

Digital Microfluidics/Electrowetting

There is a need to miniaturize, automate and simplify nucleic acid tests, immunoassays, and other bio-molecular assays in order to achieve desired levels of specificity, sensitivity, detection speed, and long-term stability.  The Microfluidics Research Lab is exploring the use of electrostatically actuated motion of sub-micro-liter droplets, i.e. electrowetting, to develop biosensors and to automate laboratory processes that have traditionally been performed using liquid-handling robots, micro-titer plates, and translation stages.  The lab is equipped with state-of-the-art microfabrication instruments to make electrowetting and microfluidic chips for performing biological and chemical protocols with the aim of incorporating them into compact, handheld systems, small footprint laboratory instruments, and lab automation-compatible systems.

 Sample Preparation for Molecular Diagnostics

The focus of this research is on bio-analytical methods and device development for nucleic acid diagnostics. We have ongoing projects on: (1) sample preparation using miniaturized mechanical lysis methods, (2) thermally-controlled DNA amplification systems integrated with compact optical fluorescence systems, and (3) chip-based free-solution capillary electrophoresis of short oligonucleotides. The efforts address the ability to rapidly detect the presence of bacterial and viral pathogens in various samples.

 Mathematical and Computational Modeling in Systems Biology

We apply methods from the theory of nonlinear dynamical systems to model the interactions of genes and proteins within a cell. Both deterministic and stochastic methods are used to examine models that arise based on biological knowledge of the complex feedback systems within such networks.