The role of the bioprocess design in the development of a complete plant design. The reiterative nature of design. Equipment design. Types of bioreactor, purification columns, filters, heat exchangers, nano-filters, virus inactivation reactors and their applications in biotechnology. Design and scale up of each equipment. Process equipment costs and sources of data, cost indices: plant capital cost evaluation, typical distribution of plant capital costs and operating costs. Instrumentation: symbols, subdivision of the process streams and use of control systems: typical applications of flow, pressure, level and temperature control. The concept of loss prevention, Sis Sigma analysis and quality by design (QbD) in a biopharmaceutical industry setting: Doing a job safely, attitudes of mind. Management of safety: Factory Acts; Health and Safety at Work Act: production, storage and transport. Project review procedure: risk assessment, research and development, design, construction and operation. Identification of hazards. Inherently safe design. Hazan and hazard analysis. Scope of computer-aided process engineering and computer-aided design in process engineering applications. Process flow-sheeting, topology analysis, sequential and simultaneous solution methods. Process flow-sheet simulation.(MEB 410)
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