This course will focus on the translation of genomic data into actionable clinical information. Students will use role-playing and written reports to gain experience conveying genomic analysis results to genetic counselors and clinicians. Special attention will be paid to crafting variant significance reports using HGVS nomenclature. Case studies and team-based learning activities will be used to follow patients from sample collection, test selection, data acquisition, results determination, to suggested clinical action. Best practices for genomic variant curation and patient documentation will be emphasized.