The course will focus on developmental mechanisms clinically oriented to human genetic disease and birth defects. We will explore the process of human development from gametogenesis, fertilization, gastrulation, to birth. The course will take a systematic approach to human embryonic and fetal development with early focus on the stages of embryological development, signaling pathways, and the establishment of germ layers and eventually weaving in complex body systems and their intricate relationships with one another. The discussion of major body systems will begin with their organogenesis and anatomy throughout normal development, followed by case studies analyzing potential developmental anomalies, effects of teratogens, and practice in differential diagnosis. Online lectures including information relevant to required textbook readings as well as video animations will enable the student to be exposed to a deep understanding of human embryological development as it relates to clinical findings and research. Class time will incorporate a review of online lectures, clinical case studies, group work, and literature review to enhance and strengthen understanding of developmental concepts.