Introduction to (bio) reaction engineering. Definition of terms, classification of (bio)reactions , kinetics of reaction, rate and order of reaction, methods of determination of the order and rate of reaction. Arrhenius equation. (Bio) Reactor design and performance. Types or reactors. Batch reactors, semi-batch and continuous (perfusion) bioreactors. Mixed flow and plug flow. Calculation and comparison of performance and reactor size. Residence time distributions; E, F and C curves and their application. Methods of measurements of RTD. Models of non-ideal flow, dispersion model and dispersion coefficient, closed and open vessels. Tank in series model and laminar flow models. Bioreactor integration into the process. Process considerations – reaction medium (media composition) – product recovery (yield and titre). Process design methodology. Biopharmaceutical industry examples and case studies. Bioreactor control and operation.
MEng program students only