This course delves into a few ground-breaking original research papers that have shaped the concepts and technologies of modern biomedical research, with a special focus on cancer. The research contributions discussed here start with the discovery of oncogenes and quickly gathers pace to discuss paradigm-shifting research papers published within the last few years. The goal is to understand the logic and principles of doing biological experiments: the importance of models and hypotheses, testable versus untestable hypotheses, controls, the limits of interpretation dictated by the results, how changing paradigms influence the progress of science. A few of the chosen publications are considered classic; their approaches to addressing the unknown questions of the day and their conceptual contributions remain valid even today. Others, those focusing on deep sequencing of cancer genomes and single-cell studies, are more recent but have already begun to impact our understanding of cancer biology. (ALS 481A)
Undergraduate coursework in genetics, biochemistry and cell biology
Celebrating 25 years of innovation! 25.kgi.edu.