PHAR 303
SSS5: Genetic Control of Cell Structure and Function, Genes, and Pharmacogenomics

A study of the basic concepts of mammalian biochemistry regarding biosynthesis of proteins, nucleic acid structure and function in gene expression at the cellular level in both normal and disease states. Additionally, there is a review of nucleotide metabolism and an introduction to the pharmacology of antineoplastic agents. The genetic mechanisms/basis of polymorphisms in the pharmacokinetics and pharmacodynamics of representative therapeutic drugs are emphasized. The impact of epigenetics and environmental factors on individualizing therapy, the use of biomarkers and diagnostics in determining therapeutic choices, and use of biotechnology in drug therapy will be discussed.