Literature Mastery Seminar: Nickie Toloueenia, MS Student - Keck Graduate Institute Skip to main content
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Join us as Master of Science in Applied Life Sciences student Nickie Toloueenia speaks about the Amodiaquine-genomic portrait of microbes and discovering AQ-mediated synthetic lethality.

“The repurposed quinoline, Amodiaquine (AQ), has been shown to be effective against Cathepsin B dependent pathogens. AQ has also been shown to have an inhibitory effect in fungi that have defects in cell wall composition but cannot do this on its own in the wildtype fungus. The opportunistic pathogen, Candida albicans, can have severe outcomes in immunocompromised individuals. By testing for the inhibitory effect of AQ on a library of 2,000 knock out genes of Candida albicans, we strive to find mutants that AQ will inhibit. If the identified gene is already targeted by a known anti-fungal, we will attempt to combine AQ with it in search for synergism of efficacies. The goal of this thesis is to identify the mutant gene, find an antifungal that either blocks the gene or the product of the gene identified in the wild type and synergize it with AQ.

Friday, October 12, 2018 at 12:00 p.m.
Building 517, 138 Classroom

A pizza lunch will be provided. Please RSVP so that we may ensure all attendees are accounted for.


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October 12, 2018
12:00 pm - 1:00 pm
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KGI Bldg. 517, Room 138
517 Watson Drive
Claremont, CA 91711 United States


Henry E. Riggs School of Applied Life Sciences