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Join us as Master of Science in Applied Life Sciences student Jada Mack speaks about decorating red blood cell exosomes for CRISPR-Cas9 delivery across the blood-brain barrier.
“The most common and prevalent neurodegenerative disease is dementia, with Alzheimer’s and Parkinson’s being the most common occurring. Currently, there is no cure for these diseases due to the lack of understanding in the methodology of disease progression and the failure of currents drugs to cross the blood-brain barrier (BBB). CRISPR-Cas9 has been proposed to be a possible form of cure for neurodegenerative diseases, but the current method of getting it to cross the BBB can be invasive, cause immune responses, and is costly. In recent studies, exosomes have been explored has potential drug delivery vehicles and in some cases is shown to target and cross the BBB. Moreover, erythrocyte-derived exosomes are easy to isolate from patients and are very abundant, providing a less invasive and cost-effective alternative to other delivery methods. In this study, I will investigate the potential use of erythrocyte-derived exosomes as a novel method of delivering CRISPR-Cas9 across the blood-brain barrier.”
- Thesis Advisor: Dr. Kiana Aran, Assistant Professor, Medical Diagnostics and Therapeutics, Keck Graduate Institute
- Committee Member: Dr. Rachita Sumbria, Associate Professor of Biopharmaceutical Sciences, Keck Graduate Institute
Date: Friday, October 11, 2019 at 12:00 p.m.
Location: Building 121, Classroom 1110
Snacks will be provided. Please feel free to bring your own lunch to eat during the seminar.