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Join us as Master of Science in Applied Life Sciences student Ryan Elshimali speaks about utilizing EMP2 to identify breast cancer patients at risk for metastasis and relapse.
“Over the last few years, the use of circulating tumor cells (CTCs) as “liquid biopsies” of solid tumors has gained momentum. However, current methodologies to recover CTCs from women with breast cancer (BC) poorly discriminate between early-stage patients amenable to surgical therapy and advanced-stage patients receiving chemotherapy. Moreover, there are no assays currently approved which can predict patient response. As breast cancer is the second most common cause of cancer deaths in women, exploring novel prognostic and diagnostic markers in BC CTCs is of great significance. To this end, we have recently identified a diagnostic marker, epithelial membrane protein-2 (EMP2). EMP2 is highly expressed in all subtypes of BC, with over 90% of TNBC patients showing expression of the protein. New data suggests that EMP2 increases the tumorigenic potential and resistance of cancer cells, suggesting it may be a marker to track cells commonly referred to as “cancer stem cells”. We seek to show antibodies that recognize EMP2 can capture CTCs to diagnose and stage disease. We further propose to characterize EMP2 + CTCs as a means for improved personalized medicine.”
Date: Monday, October 7, 2019 at 12:00 p.m.
Location: Building 121, Classroom 1110
Snacks will be provided. Please feel free to bring your own lunch to eat during the seminar.
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