PhD Dissertation Graduate Student Literature Seminar – Ijeoma J. Nnadozie, PhD Student– “Identification and Comparison of Structural Variants found Colorectal Cancer Patients from Diverse Populations”

Please join us for Ijeoma J. Nnadozie’s PhD Dissertation Graduate Student Literature Seminar Presentation on:

One of the primary mechanisms of genetic mutation in cancer is structural variation, which involves the deletion, insertion, or reordering of genomic segments ranging from a few kilobases to entire chromosomes. While the role of structural variants in cancer development is complex, evidence of the clinical significance of structural variation has increased with the rapid development of long-read whole genome sequencing technology. Colorectal cancer is a complex illness, closely linked to lifestyle factors and genetic risk. Although highly penetrant germline mutations account for less than 5% of colorectal cancer cases, its estimated heritability ranges between 12%-35%. Numerous studies have employed copy number variation (CNV) arrays and short-read sequencing to investigate these SVs, which have been found to cause copy number modifications of oncogenes and deletions of tumor suppressor genes. NGS analysis in patients of various ethnic backgrounds is critical for comprehending the complexity and heterogeneity of solid tumors such as colorectal cancer, which often harbor multiple genetic mutations. Genomic analysis technologies offer crucial insight into the precise mechanism of action and resistance of targeted agents for treating CRC, by revealing its heterogeneity. This knowledge helps refine current management strategies for treating the disease.

Date:   Wednesday, May 3, 2023

Time: 12:00 – 1:00 p.m

Location:  535 Bldg. – 152 Classroom Via Zoom