PhD Dissertation Progress Presentation: Karen Yrene Paco Mendivil, PhD Student - Keck Graduate Institute May 14, 2019, 12:00 pm Skip to main content
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Headshot Karen Yrene Paco Mendivil 1

Join us as PhD in Applied Life Sciences student Karen Yrene Paco Mendivil speaks about Alzheimer’s disease active immunotherapy using the Tobacco Mosaic Virus (TMV) by targeting a structural domain of pathological Tau.

“In neurodegenerative diseases there has been a significant effort focused on active immunizations for involved protein forms present in these diseases, however targeting the unstable pathological forms remains a challenge.

Alzheimer’s Disease affects more than 35 million people worldwide. As result of recent failed clinical trials targeting amyloid beta protein, the scientific community has directed more attention to the hypothesis based on the tau protein aggregates in Alzheimer’s patients.

One therapeutic approach is using antibodies to target Tau to prevent these aggregations. Active immunotherapy is a promising option because it engages the patient’s own immune system to offer long-lasting effects.

The microtubule binding domain in the tau protein is involved in the formation of neurofibrillary tangles, and it has a domain that form the pathological structure of Tau. In this project we propose the development of a therapeutic vaccine using the Tobacco Mosaic Virus (TMV) as a scaffold to expose immunogenic epitopes of a structural domain from the pathological tau to stimulate the patient’s immune system.

  • Date and time: Tuesday, May 14, 2019 at 12:00 pm
  • Location: Building 517, 165 Classroom


May 14, 2019
12:00 pm - 1:00 pm PDT
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KGI – Online ZOOM Link (will be emailed prior to end of day April 22nd, 2020)
517 Watson Drive
Claremont, CA 91711 United States


PhD in Applied Life Sciences Program
(909) 607-0120
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