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Join us as PhD in Applied Life Sciences student Karen Yrene Paco Mendivil speaks about Alzheimer’s disease active immunotherapy using the Tobacco Mosaic Virus (TMV) by targeting a structural domain of pathological Tau.
“In neurodegenerative diseases there has been a significant effort focused on active immunizations for involved protein forms present in these diseases, however targeting the unstable pathological forms remains a challenge.
Alzheimer’s Disease affects more than 35 million people worldwide. As result of recent failed clinical trials targeting amyloid beta protein, the scientific community has directed more attention to the hypothesis based on the tau protein aggregates in Alzheimer’s patients.
One therapeutic approach is using antibodies to target Tau to prevent these aggregations. Active immunotherapy is a promising option because it engages the patient’s own immune system to offer long-lasting effects.
The microtubule binding domain in the tau protein is involved in the formation of neurofibrillary tangles, and it has a domain that form the pathological structure of Tau. In this project we propose the development of a therapeutic vaccine using the Tobacco Mosaic Virus (TMV) as a scaffold to expose immunogenic epitopes of a structural domain from the pathological tau to stimulate the patient’s immune system.“
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