PhD Literature Mastery Presentation– Alexander Burns – “Exosomes as Delivery Vectors for Cells and Theranostics”

Please join us for PhD student, Alexander Burns’ PhD Literature Mastery Presentation on:

R&D efforts around exosomes have been ongoing for more than 40 years, with over 80 active clinical trials investigating the use of exosomes as a potential tool for therapy and diagnostics (theranostics), and as a potential alternative to viral vectors. The research efforts have focused on the mechanism of exosomes in cells (i.e., their role in cell proliferation, homeostasis, apoptosis and angiogenesis), exosomes as vectors for delivery of biomolecules (such as small-molecule drugs, proteins, DNA and RNA) for therapeutic purposes, exosomes as biomarkers for diagnostics, and exosomes for tissue regeneration therapy. The development efforts have focused on development of production and purification bioprocesses and quality-control tools for exosomes. But exosomes have also been investigated for their role in disease, with most focus on cancer. Exosomes have been found to participate in cancer tumorigenesis, metastasis, and development of chemotherapy resistance. Although exosomes are seen as a double-edged knife, they have potential as a tool for therapy and diagnostics (theranostics potential). This seminar will focus on a literature review on the current state of exosomes as a tool for theranostics (MOA, theranostics potential, clinical trials, manufacturing platforms, and QC tools for exosomes).

Date: Tuesday, April 25, 2023

Time: 12:00 – 1:00 pm (And via Zoom)

Location: 535 Bldg – 152 Classroom