PhD Literature Mastery Presentation – Jason Lee, PhD Student – “Modeling Fluidic Shear Stress Found in Various Bioprocess Systems and its Effect on T Cells”

Please join us for KGI PhD student Jason Lee, Process Engineer II, Kite Pharma Ph.D. Literature Mastery presentation.

The development and approval of autologous CAR-T cell therapies places an increase demand on manufacturing capacity. There are 5 commercially approved autologous CAR-T cell products with over 500 cell therapies in development[1]. Implementation of automation technologies can reduce the reliance on skilled manufacturing technicians, increase process robustness, and decrease variability. The foundation of understanding T cell behavior in various environments may affect growth, performance, efficacy, and ultimately patient response. Identifying and understanding mechanisms (e.g., shear stress, temperature shift, pH levels) and their effects will provide a foundation for future cell therapy processes and related equipment. Developing a scale-down shear device to simulate and predict the shear stress found in complex bioprocess equipment can shorten process development timelines and improve the throughput of screening of new technologies.

Date:  Thursday, December 8, 2022

Time:  12:00 – 1:00 p.m.

Location:  535 Bldg. – 152 Classroom and Via Zoom (See Zoom Link in Outlook Invite)