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Join us as PhD in Applied Life Sciences student Noa Park speaks about: “Antimicrobial Preservatives for Vaccines Delivered as Multi-Dose Products”
The objective of this research project is to identify suitable antimicrobial preservatives to protect biologics delivered as parenteral products against microbial growth. Of the roughly 350 parenteral products currently available on the global market, about a third are manufactured in multi-dose formats. The distinct burden of developing multi-dose products is the need for a safe and efficacious antimicrobial preservative that will inhibit unwanted microbial growth without compromising the vaccine’s active ingredient. Through antimicrobial effectiveness testing (AET) on test organisms (e.g., E. coli, C. albicans, A. niger) and stability studies for biological activity, the viability of test preservatives (e.g., Phenol, Benzyl alcohol, m-Cresol) will be investigated for surrogates of select COVID-19 vaccine products (e.g., mRNA, AAV, recombinant protein). The outcome of this project will be novel insight for regulatory assessment and rapid adoption of multi-dose products to meet various global demands in vaccine manufacturing.