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Please join us for our next Research Seminar Series talk by Dr. Kiana Aran on Using Biology-gated Transistors for Multiomics Applications:
Until now, life science data was comprised of static snapshots. Biology-gated graphene field effect transistors (gFETs) leverage the high sensitivity and biocompatibility of graphene, enabling a digital connection to biology. The small microfabricated nature of the gFET chip allows for multiple channels, each containing different bioreceptors. This multiplexing capability lends itself to the detection of multiple biomarkers leading to higher specificity, lower limits of detection, and multiomic capabilities. We have used these biology-gated gFETs for multiple different applications including click-chemistry to identify circulating blood biomarkers, deactivated CRISPR-Cas9 and guide RNA complexes to identify mutant genes, and antibodies to detect Zika virus through a previous collaboration with the CDC. The versatility of gFETs allows them to be incorporated into different hardware platforms from a point-of-care handheld reader to high throughput automated liquid handlers and combined with cloud-based computational power (such as ML and AI) to meet multiple applications with multiomic capabilities. This enables virtually live insight to life and biology, similar to how people today have instant insight to global news and events, financial information, and social media activities.