Research Seminar Series: Dr. Stan Louie - "How to Exploit Nature’s Way to Resolve Chronic Inflammation" - Keck Graduate Institute January 29, 2021, 12:00 pm Skip to main content
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Please join us for our Research Seminar Series with Dr. Stan Louie, Professor of Clinical Pharmacy & Director of Clinical Experimental Therapeutics Program at the USC School of Pharmacy, Department of Clinical Pharmacy

Abstract:

Chronic inflammation has been associated with a number of disorders included atherosclerosis, diabetes, obesity, NASH, Parkinson’s Disease, and Alzheimer’s Disease.  Most recently, chronic inflammation has been linked to neutrophil mediated inflammation. In this process, extravasated neutrophils produces excess reactive oxygen species (ROS), which then promote the release of its nuclear contents.  This process is more commonly known as neutrophil extracellular traps (NETs or NETosis). 

Following sequestration into affected tissue, neutrophils will upregulate expression of NADPH oxidase, which can generate reactive oxygen species (ROS). Intracellular generation of ROS will activate neutrophil elastase and peptidyl arginine deiminase-4 (PAD-4) leading to deamination of arginine residues found on histones.  Citrullinated histone will enhance unwinding of the DNA, where the translocation of neutrophil elastase will promote DNA expulsion. 

The use of lipoxin analogues were capable of resolving chronic inflammation through clearance of neutrophils. In this presentation, we have shown the effectiveness of lipoxin analogues in the promote chronic inflammation resolution.

Date/Time: Friday, January 29, 2021 – 12:00 – 1:00 p.m.

Location:  Via Zoom