Research Seminar Speaker Series - Dr. Jim Sterling - "Biocondensates: Membraneless Organelles that Organize Cellular Biochemistry" - Keck Graduate Institute October 21, 2022, 12:00 pm Skip to main content
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Please join us for this presentation by our own KGI faculty member, Dr. Jim Sterling, Professor and PhD Program Director, Henry E. Riggs School of Applied Life Sciences

Many macromolecular biocondensates have been observed as so-called intracellular membraneless organelles since their discovery in 2009 in the Hyman lab in Dresden Germany. Commercialization of drug discovery technology based on biocondensates is underway. Biocondensate formation has been demonstrated to be a process of liquid-liquid phase transition in the cell. Many of these structures are based on the interaction of nucleic acids and intrinsically-disordered protein domains that offer a new paradigm for biochemical kinetics, and recruitment of so-called clients into the dense liquid phase can further accelerate biochemistry. As a new kind of structure-function in the cell, pathological condensates have been associated with specific human diseases. Recently extracellular biocondensates have been reported. The role of ion-specific behavior and hydration biophysics on extracellular glycosaminoglycans is being studied with collaborators and deeper insight into the molecular mechanisms is sought by applying molecular dynamic simulations and mean-field modeling of these structures.  

Date:  Friday, October 21, 2022

Time:  12:00 – 1:00 p.m.

Location: 121 Bldg. – 1111 Classroom and Via Zoom (See Outlook invite for Zoom Link)

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