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Please join us for this presentation by our own KGI Faculty member, Dr. Subhrajit Bhattacharya, Assistant Professor, Pharmaceutical and Applied Life Sciences
NMDARs (N-Methyl-D-Aspartate receptors) are an essential component of the excitation/inhibition complex in the brain that regulates precipitation of different neurodegenerative diseases. Dysregulated spatial and temporal expression of these receptors and their interactions with signaling molecules such as neural cell adhesion molecule (NCAM) have been implicated in Epilepsy, AD and schizophrenia. My seminar focuses on our current research/collaborations in this field where we investigate the role of NMDARs in different areas of the brain and their role in disease progression. For example, we show that removal of NCAM interaction in medial prefrontal cortex leads to increased transmission mediated by the GluN1/GluN2B-NMDARs, increased NMDAR-mediated extrasynaptic tonic currents, and impaired long-term potentiation. Moreover, we will revisit different drug molecules and their unique action on stoichiometrically different NMDARs.
Date: Friday, October 28, 2022
Time: 12:00 – 1:00 p.m.
Location: 121 Bldg. – 1111 Classroom AND Via Zoom (See Outlook invite to KGI Community)