Research Seminar Speaker Series: Kim Le – “Implementation of the Beacon Nanofluidic Platform into a Manufacturing Cell Line Development Process”

Please join us for our Research Seminar Speaker Series with Kim Le, Senior Scientist, Amgen, Inc.

The manufacture of therapeutic biologics relies on understanding and harnessing mammalian cells to secrete desired proteins. Generating a highly productive cell line however typically involves long timelines and resource intensive. As a result, miniaturization and automation strategies are often employed to allow for reductions in resources and higher throughput.  However, current automation approaches rely on the use of standard cell culture vessels and bulky liquid handling equipment.  The Beacon platform from Berkeley Lights offers to eliminate these bottlenecks through growing cells on custom nanofluidic chips. Berkeley Lights’ OptoElectro Positioning (OEP) technology projects light patterns to activate photoconductors that gently repel cells to manipulate single cells on nanofluidic culturing chips.  Integrate fluorescence imaging capabilities allow for analytics of cells in real time. 

We demonstrate the ability to generate a diverse and comparable set of candidate clonal cell lines with reduced resources.  Additionally, we performed validation experiments to demonstrate that the Beacon process provides high assurances of clonal derivation and zero cross-contamination events.  Together, the Beacon enables high quality production cell lines with improved data packages, detailed tracking, high assurance of clonality, reduced resources, and decreased cycle times.

Date: Friday, October 22, 2021

Time: 12:00 – 1:00 p.m.

Via Zoom: Zoom Link will be on Outlook invite to KGI Community