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Please join us for our Research Seminar Series Speaker, Larry Grill, Dean of Research and Research Professor at KGI on:
Monoclonal antibodies are increasingly used in multiple therapies, and especially in cancer treatment. It is always a challenge to identify the best monoclonal antibody variable region for the given target. In the case of the monoclonal antibodies to treat COVID-19 patients, the changing nature of the SARS-CoV-2 spike protein has rendered the earlier version of them substantially less effective. A better approach is to create an antibody fusion product in which the variable region is substituted with the SARS-CoV-2 target regions of the unchanging ACE2 receptor, to which the virus must bind to infect a cell. The SARS-CoV-2 virus will always bind to the antibody-ACE2 fusion product and provide a target for the Fc receptors of the immune cells, which will subsequently eliminate the virus. The work in our lab focuses on Fc fusion therapeutics for ZIKA and rabies virus infections.
Day: Friday, March 10, 2023
Time: 12:00 – 1:00 p.m.
Location: 121 Bldg. – 1111 classroom