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Join us as Assistant Professor Dr. Zhen Chen speaks about the “Non-coding RNA-Mediated Endothelial Stress Response in Diabetes“.
Date: Friday, January 31, 2020, at 12:00 p.m.
Location: Building 121 Classroom 1110
Abstract: Lining the critical interface between circulating blood and vessel wall, endothelial cells (ECs) dynamically sense and respond to various stress conditions throughout the body. Such stress response is essential to maintain the function of ECs as well as surrounding tissues and organs. Our study has focused on non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are important regulators in gene expression and endothelial function. I will discuss our efforts in two areas: 1) key lncRNAs in regulating endothelial hemostasis and dysfunction related to diabetic complications; and 2) miRNA-associated mechanisms in mediating endothelial-adipose tissue crosstalk and the relevance in obesity and type 2 diabetes. The identified mechanisms may provide new insights into endothelial dysfunction associated with hyperglycemia and inflammation. Furthermore, these studies may suggest novel strategies to expand the therapeutic repertoire for obesity, type 2 diabetes, and related complications.
Snacks will be provided. Please feel free to bring your lunch to eat during the seminar.