The Center for Biomarker Research is dedicated to education and applied research activities that expand knowledge and development of biomarkers as a tool for diagnostics, drug development, and the practice of medicine in the 21st century.
Collaborating with academic, corporate, and not-for-profit partners, the Center for Biomarker Research seeks to spur innovation in approaches to the discovery and commercialization of new biomarkers that address unmet diagnostic needs. The Center is investigating new biomarkers for rare and other diseases that are difficult to diagnose with existing in vitro diagnostic tests. Currently utilizing flow cytometry to investigate cellular biomarkers, the Center intends to expand its applied research efforts to genomic and proteomic biomarkers as well.
By partnering with the government agencies, foundations, and industry partners, the Center explores biomarkers in rare disease populations. These activities will facilitate biomarker discovery and provide a means of classifying and stratifying disease populations. From this research, a new database of rare disease biomarkers is being created which will be accessible to academic and corporate communities for their own research.
What are Biomarkers?
Biomarkers are molecular indicators used to measure a range of physiological conditions. They hold great promise in the fight against disease and the development of personalized medicine because they reveal the physiological state of an individual. Biomarkers can be used to diagnose disease, monitor disease progression and response to therapy, and are targets for development of new drugs.
- To provide world-class education to KGI students and the community at large on biomarkers and personalized medicine
- To successfully research and commercialize the use of biomarkers as diagnostic markers of disease
The Center for Biomarker Research educates graduate students at KGI and undergraduate engineering students at Harvey Mudd College in the development of diagnostic tools for biomarker discovery. Students learn to operate in a Good Laboratory Practice facility that handles human samples, and they gain valuable hands-on experience in quality assurance, assay validation and regulatory compliance, areas that are not commonly addressed in an academic setting.
The Center for Biomarker Research’s laboratory contains an array of equipment to support its research efforts:
- BCI FC500 MPL Cytometer
- BCI CEQ 8800 DNA Sequencer
- BCI CEQ 8000 DNA Sequencer
- BCI ProteomeLab PF2D HPLC
- BCI L8-80M Ultracentrifuge
- Biomek FX Dual Arm
- BCI P/ACE MDQ CE SystemBCI
- DU 640i Spectrometer
- Sorvall RT 6000D Centrifuge
- BCI Microfuge 22R Centrifuge
- ThermoFinnigan ESI MS/MS
- Typhoon Scanner
- BCI J2-21 Centrifuge
- BSL2 facilities for Cell Culture