Mechanisms of Disease, Neurobiology/Neuropharmacology, Systems, Computational, and/or Evolutionary Biology, Therapy Discovery and Development
Dr. Zambon joined KGI in July 2014. Dr. Zambon’s research interests involve understanding how cell signaling pathways and transcriptional circuits drive cell fate decisions and pathological tissue remodeling. His PhD training at the University of California San Diego was in the area of molecular pharmacology and G-protein coupled receptor signaling; one of largest classes of therapeutic drug targets.
Dr. Zambon’s postdoctoral training at the Gladstone Institute of Cardiovascular Disease/UCSF was in genomics and systems biology, where he developed bioinformatics approaches to identify transcription networks and pathways that control cardiac myocyte cell division during development and remodeling.
The Zambon lab at KGI currently focuses research in two areas:
Hsu T, Mallareddy J, Yoshida K, Bustamante, V, Lee T, Krstenansky J, Zambon AC (2019) Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human m-opiate receptor 1 (OPRM1) expressing cells. Pharmacol Res and Perspect. In press.
Walker JV, Zhuang H, Singer D, Gao Y, Grayson PRC, Liu Y, Wang S, Karbanova J, Lee T, Ardu S, Lail Q, Liu J, Tredwin C, Kassam M, Chen S, Zambon AC, Corbein D, Abdalla B, Hu B (2019) Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nature Commun. In press
Neri T, Hiriart E, Vliet PV, Faure E, Norris RA, Fahrat B, Jagla B, Lefrancois J, Moore-Morris T, Zaffran S, Faustino R, Zambon AC, Sugi Y, Desvignes JP, Salgado D, Levine R, Luis de la Pompa J, Terzic A, Evans S, Markwald R, and Michel Pucéat (2019) Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis. Nature Commun. 10: 1929.
Singer D, Thamm K, Zhuang H, karbanova J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PR, Gulsen T, Liu K, Ardu S,Wann A, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B (2019) Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 38. 2
Zambon AC*1, Cannon L1, Cammarato A1, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R* (2017) Expression patterns of cardiac aging in Drosophila. Aging Cell. 16:82-92.
Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch A, Nobrega M, Evans S, Zambon AC (2015) Hif1a represses cell stress pathways to allow proliferation of hypoxic fetal cardiomyocytes. Developmental Cell. 33:507-21.
Selected from 53 publications in pubmed