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Han

Derick Han, PhD

Associate Professor of Biochemistry and Pharmacology

Areas of Expertise

Mechanisms of Disease

Contact Information

Location: Building 215, room 201
Phone: 909.607.0192
derick_han@kgi.edu
More information
  • About
  • Selected Publications
  • Courses
  • Media

Dr. Han, who joined KGI in June 2013, has spent much of his career researching the role of mitochondria in physiology and pathophysiology, particularly in the liver. As a post-doctoral researcher and then an assistant professor of research medicine at the Keck School of Medicine of University of Southern California (USC), his focus has been largely on mitochondrial remodeling in the liver caused by metabolic stress, such as alcohol feeding and obesity.  He also has been engaged in research examining signal transduction pathways that mediate drug-induced liver injury.

Dr. Han was the recipient of USC’s Research Center for Liver Diseases Pilot Project Award and the Zumberge Research and Innovation Award, and has been principal and co-principal investigator on several grants from the National Institutes of Health. His teaching experience includes serving as a lecturer and instructor at USC’s School of Pharmacy and as an adjunct professor of biochemistry at Occidental College in Los Angeles. Dr. Han holds a PhD in molecular pharmacology and toxicology from USC and B.A. in sociology and biochemistry from the University of California, Berkeley.

H-index = 32; average citations/article = 67; total citations = 3469

Garcia J, Decker C W, Sanchez SJ, Ouk JM, Siu KM, and D Han. Obesity and steatosis promotes mitochondrial remodeling that enhances respiratory capacity in the liver of ob/ob mice. FEBS letters (2018) 592:916-927.

Han D, Johnson HS, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Rao MP, Cadenas E and N Kaplowitz. Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radical Biology and Medicine (2017) 102:100-110.

Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, and N Kaplowitz. Receptor Interacting Protein Kinase-1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology (2015) 62: 1847-1857. (Highlighted in an editorial)

Chang AHK, Sancheti H, Garcia J, Kaplowitz N, Cadenas E and D Han. Respiratory Substrates Regulate S-Nitrosylation of Mitochondrial Proteins through a Thiol-Dependent Pathway. Chemical Research  in Toxicology (2014) 27:794-804.

Saberi B, Ybanez MD, Johnson HS, Gaarde W, Han D and N Kaplowitz, N. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways. Hepatology (2014) 59: 1543-54.

Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, and N Kaplowitz. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends in Pharmacological Sciences (2013) 34:243-53.

Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Dara L, Cadenas E, Tsukamoto H, and N Kaplowitz. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. Journal of Biological Chemistry (2012) 287:42165-79.

Win S, Than TA, Han D, Petrovic LM and N Kaplowitz. c-Jun N-terminal Kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. Journal of Biological Chemistry (2011) 286: 35071-78.

Garcia J, D Han, Sancheti H, Yap LP, Kaplowitz N, and E Cadenas. Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. Journal of Biological Chemistry (2010) 285: 39646-54.

Yap LP, Sancheti H, Ybanez MD, Garcia J, Cadenas E, and D Han. Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol (2010) 473: 137-47.

Yap LP, Garcia JV, Han D, and E Cadenas. Role of nitric oxide-mediated glutathionylation in neuronal function: potential regulation of energy utilization. Biochem J (2010) 428: 85-93.

Antunes F, and D Han. Redox regulation of NF-κB: From basic to clinical research. Antioxidant and Redox Signaling (2009) 11: 2055-6.

Han D, Ybanez MD, Ahmadi S, Yeh K, and N Kaplowitz. Redox regulation of tumor necrosis factor signaling. Antioxidant and Redox Signaling (2009) 11: 2245-63.

Kaplowitz N, Shinohara M, Liu ZX, and D Han. How to protect against acetaminophen: don’t ask for JUNK. Gastroenterology (2008) 135: 1047-51.

Saberi B, Hanawa N, Shinohara M, Gaarde W, Kaplowitz, N, and D Han. Regulation of H2O2-induced necrosis by Protein Kinase C and AMP-activated kinase signaling in primary cultured hepatocytes. American Journal of Physiology: Cell Physiology (2008) 295: C50-63.

*selected from 55 publications

PHAR 5315: Principles of Drug Action
PHAR 5335: Integrated Series 2 – Endocrinology and Urology
PHAR 5365: Recitation 2
SCI 3100: Biochemistry
SCI 5300: Pharmaceutical Discovery
PPC Student Samantha Kuong Pursues OB-GYN Career to Raise Awareness of Endometriosis and Guide Women Through the Birthing Process
PharmD Student Dharam Amin Explores the Impact of Alcohol on the Blood-Brain Barrier for the Lee Summer Student Fellowship Program
New Potential Link Between Alcoholism, Fatty Liver Disease, and Alzheimer’s Disease Identified by Dr. Derick Han’s Team
NIH Diversity Grant Recipient Frankey Sanchez Continues to Challenge Herself and Surpass Her Expectations
Dharam Amin Takes Advantage of KGI’s Community College to PharmD Accelerated Program While Challenging Assumptions About the Pharmaceutical Industry
From Competitive Ice Hockey to Pre-Health, KGI Student Candy Lu Triumphs Over Challenges and Hits Her Stride
Raised in the World of Professional Boxing, PPC Student Nicole Diaz Discovers the Fusion Between Sports and Medicine
Leslie Contreras Overcomes Hardship as Daughter of El Salvadoran Immigrant, Fueled by Her Passion for Community Outreach
Veteran Aldo Arce Receives NIH Diversity Grant to Research Alzheimer’s Disease Under Dr. Derick Han
Zijie Zhang Builds Upon Passion for Research and Pharmacy in KGI’s Pre-Pharmacy Enrichment Program
Incoming PharmD Student Angie Aceves Guided to Forge a Unique Path in Pharmacy
KGI’s PrEP Offers an Inspirational, Eye-Opening Experience for Aspiring Pharmacists
KGI Professors Awarded NIH R01 Grant to Investigate Link Between Alcoholism and Alzheimer’s Disease
Summer Pre-Pharmacy Program Highlights Professional Practice and Opportunities
Derick Han Receives NIH Grant to Research Adaptation of Liver Mitochondria to Alcohol
Professor Ian Phillips Honored with Lifetime Achievement Award

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