Eddie Crabbe has more than 12 years experience in aerobic and anaerobic fermentation process development for recombinant protein and bioenergy production, technology transfer, and manufacturing support. Currently, Eddie works at Allergan in Irvine, California as a Senior Scientist in Biologics Development Process Sciences. In this role, he leads the design, development, scale up, characterization, and transfer of fermentation and primary recovery processes for the production of biologics and enzymes. He provides technology transfer expertise to in-house and external development and commercial manufacturing partners as well as contributing to manufacturing sections for CMC regulatory filings.
Prior to joining Allergan, he worked as a Senior Scientist in Kam Biotechnology in Surrey, Canada where he developed a lab scale platform for microbial hydrogen production from biological waste streams, provided proof-of-concept for a two-step continuous bioethanol production process, and supported manufacturing of bio-based (fungal and bacterial) products for applications in wastewater treatment.
Eddie has a PhD in Food Science and Technology (Microbial Biotechnology option) from Kyushu University, Fukuoka, Japan, and holds a BS (honors) and an MPhil in Biochemistry from the University of Ghana, Legon, Ghana. He also undertook post-doctoral studies in methane steam reforming to hydrogen TonenGeneral Corporation (an ExxonMobil affiliate in Saitama, Japan) and lysine production by a thermo-tolerant bacillus species from methanol in Professor Mike Flickinger’s Lab in the Biotechnology Institute at the University of Minnesota, St. Paul.
Ishizaki, A., Crabbe, E., Lee, T. M., Todd, J. T., and Yoshino, S. (1998). Fermentative acetonebutanolethanol production by Clostridium saccharoperbutylacetonicum N14 (ATCC 13564) from palm oil mill separator sludge. Recent Res. Develop. in Agr. and Biol. Chem., 2, 4156.
Ishizaki, A., Michiwaki, S., Crabbe, E., Kobayashi, G., Sonomoto, K., and Yoshino, S. (1999). Extractive Acetone-Butanol-Ethanol Fermentation Using Methylated Crude Palm Oil as Extractant in Batch Culture of Clostridium saccharoperbutylacetonicum N1-4 (ATCC13564). J. Biosci. Bioeng. 87(3), 352-356.
Cirilo, N-H., Crabbe, E., Kobayashi, G., Sonomoto, K., and Ishizaki, A. (2000). pH-dependent continuous lactic acid fermentation by Lactococcus lactis IO-1 using hydrolyzed sago starch. J. Fac. Agr. Kyushu Univ., 44(3/4), 367-375.
Crabbe, E., Nolasco-Hipolito, C.N., Kobayashi, G., Sonomoto, K. and Ishizaki, A. (2001). Biodiesel production from crude palm oil and evaluation of butanol extraction and fuel properties. Process Biochemistry 37, 65-71.
Brautaset T., Williams, M.D., Dillingham, R.D., Kaufmann, C., Bennaars, A., Crabbe, E., Flickinger, M.C. (2003). Role of the Bacillus methanolicus Citrate Synthase II Gene, citY, in regulating the secretion of glutamate in L-Lysine-secreting mutants. Appl. Environ. Microbiol. 69(7), 3986-95.
Mongi Ferchichi, Edward Crabbe, William Hintz, Gwang-Hoon Gil, Amer Almadidy (2005). Influence of culture parameters on biological hydrogen production by Clostridium saccharoperbutylacetonicum ATCC 27021. World Journal of Microbiology and Biotechnology 21, 855 – 862.
Mongi Ferchichi, Edward Crabbe, William Hintz, Gwang-Hoon Gil, Amer Almadidy (2005). Influence of initial pH of hydrogen production from cheese whey. Journal of Biotechnology 120, 402-409.
Cirilo Nolasco Hipolito, Edward Crabbe, Carmen Monterrubio Badillo, Octavio Carvajal Zarrabal, Miguel A. Morales Mora, Gabriel Pineda Flores, Manuel de A. Hernández Cortazar and Ayaaki Ishizaki (2008). Bioconversion of industrial wastewater from palm oil processing to butanol by Clostridium saccharoperbutylacetonicum N1-4 (ATCC 13564). Journal of Cleaner Production Vol. 16 (5), 632-638.