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      • Doctor of Pharmacy
      • Doctor of Philosophy in Applied Life Sciences
      • Occupational Therapy Doctorate
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      • Master of Engineering in Biopharmaceutical Processing
      • Master of Science in Applied Life Sciences
      • Master of Science in Community Medicine
      • Master of Science in Human Genetics and Genetic Counseling
      • Master of Science in Human Genetics and Genomic Data Analytics
      • Master of Science in Medical Device Engineering
      • Master of Science in Physician Assistant Studies
      • Master of Science in Regulatory Affairs
      • Master of Science in Translational Medicine
      • Postbaccalaureate Premedical Certificate
      • Postbaccalaureate Pre-PA Certificate
      • Certificate in Bioscience Management
      • Certificate in Applied Genomics
    • Schools
      • Henry E. Riggs School of Applied Life Sciences
      • School of Community Medicine
      • School of Pharmacy and Health Sciences
      • Biocon Academy
    • Summer Programs
      • Application Boot Camp
      • Bioprocessing Summer Undergraduate Internship Training and Education
      • Clinical Genetics and Bioinformatics Summer Program
      • High School Summer STEM
      • Managing Science in Biotech for Postdocs
      • Medical Device Development Bootcamp
      • PA Summer Success Program
      • Pre-Occupational Therapy Program
      • Pre-Pharmacy Enrichment Program
      • Summer Explore Health Professions
      • Summer Speaker Series
      • Summer Undergraduate Research Experience
      • Undergraduate Summer Science Courses
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      • Center for Biomarker Research
      • Center for Rare Disease Therapies
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      • Science Heritage Center
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Tolstorukov

Ilya Tolstorukov, PhD, DSc

Research Professor

Areas of Expertise

Bioprocessing and Biotechnology, Therapy Discovery and Development

Contact Information

Location: Building 215, room 126
Phone: 909.607.8564
ilya_tolstorukov@kgi.edu
More information
  • About
  • Selected Publications
  • Patents

Ilya Tolstorukov joined KGI in May 2001

2001–Present: Research Professor, Senior Research Scientist, Visiting Scientist, Riggs School, KGI.

2008–Present: Founder, Principal Scientist, Biogrammatics, Inc, Carlsbad, CA.

1991–2002: Section Head, Professor, Section for Genetics of Methylotrophic Yeasts, State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia.

1997–1998: Visiting Professor, International Center of Biotechnology, Department of Biotechnology, Faculty of Engineering, Osaka University, Osaka, Japan.

1995: Visiting Scientist, Laboratory for Electron Microscopy, Biological Centre, University of Groningen, Haren, The Netherlands.

1989–1990: Visiting Scientist, Laboratory of Eukaryotic Gene Expression, Frederick Cancer Research Facility, National Cancer Research Institute, Frederick, MD, USA

1969-1991: Junior Research Scientist, Senior Research Scientist, Leading Scientist, Group Leader, All-Union Research Institute of Genetics and Selection of Industrial Microorganisms (VNII Genetika), Moscow, USSR

  1. G.Naumov, I.Tolstorukov. 1973. Comparative genetics of yeasts. Communication 10. Re-identification of mutators of mating types in Saccharomyces. Soviet Genetics, v.9, No.1, 82-91.
  2. I.Tolstorukov, T.Dutova, S.Benevolensky, Ya.Soom. 1977. Hybridization and genetic analysis of methanol-utilizing yeast Pichia pinus. Soviet Genetics, v.13, N.2, 322-329.
  3. I.Tolstorukov, S.Benevolensky. 1982. Genetic control of cell type and complex organization of the mating type locus in the yeast Pichia pinus. Current Genetics, 5, 137-142.
  4. K.Lahthev, Y.Semenova, I.Tolstorukov, I.Van der Klei, M.Veenhuis. 2002. Isolation and properties of genetically defined strains of the methylotrophic yeast Hansenula polymorpha CBS4732. Arch. Microbiol., 177, 150-158.
  5. G.Lin-Cereghino, L.Godfrey et al. 2006. Mxr1p: a key regulator of the methanol-utilization pathway and peroxisomal genes in Pichia pastoris. Mol. and Cell Biol., V.26, No. 3, 883-897.
  6. A.J.Sunga, I.Tolstorukov and J.M.Cregg. 2008. Post-transformational vector amplification in the yeast Pichia pastoris. FEMS Yeast Res. 8, 870-876.
  7. J.M.Cregg, I.I.Tolstorukov, A.Kusari, J.Sunga, K.Madden, T.Chappell. 2009. Expression in the yeast Pichia pastoris. Review. Methods Enzymol. 463, 169-189.
  8. T.M. Ferguson, K.M. Weigel et al. 2016. Pilot study of a rapid and minimally instrumented sputum sample preparation method for molecular diagnosis of tuberculosis. Sci Rep. 20, 6:19541. doi: 10.1038/srep19541.
  9. F. Cerini, H. Gaertner et al. 2016. A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris. Protein Expr Purif. 119:1-10. doi: 10.1016/j.pep.2015.10.011.
  10. L. Sturmberger, T.G. Chappell, et al. 2016. Refined Pichia pastoris reference sequence. J Biotechnol. S0168-1656(16)30203-6. doi: 10.1016/j.jbiotec.2016.04.023.
  1. I.Tolstorukov, T.Prosvirova, et al. 1993. Strain of Candida utilis for production of single cell protein. Certificate of Invention (Russia), RU N 93019585.
  2. J.Cregg, J.Latham, M.Litton, R.Schatzman, I.Tolstorukov. 2011. Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy. US Patents 7927863, 8268582 and 8709756.
  3. J.Cregg, I.Tolstorukov. 2012. P. pastoris ADH promoter and use thereof to direct expression of proteins. US patent 8222386.
  4. J.Cregg, I.Tolstorukov. 2014. Novel P. pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using a haploid mating strategy. US Patent 8785613.

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