Infectious Disease and Immunology, Therapy Discovery and Development
Dr. Shilman, who joined KGI in March 2013, received his BS in biochemistry in 2002 from Concordia University (Montreal, Canada), and his PhD in biology in 2007 from McGill University. After completing his postdoctoral studies at Stanford University School of Medicine, he joined KGI as an Assistant Professor.
Shilman is interested in studying infectious diseases and host – pathogen interactions. His current research searches for ways to treat and prevent anthrax and Candida infections.
Jeong SY, Martchenko M, Cohen SN. Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4007-15
Martchenko M, Candille SI, Tang H, Cohen SN. Human genetic variation altering anthrax toxin sensitivity.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2972-7
Martchenko M, Jeong SY, Cohen SN. Heterodimeric integrin complexes containing beta1 integrin promote internalization and lethality of anthrax toxin.
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15583-8
Martchenko M, Levitin A, Hogues H, Nantel A, and Whiteway M. Transcriptional rewiring of fungal galactose-metabolism circuitry.
Current Biology (Cell Press). 2007 Jun 19;(17):1-7
van Het Hoog M*, Rast TJ*, Martchenko M, Grindle S, Dignard D, Hogues H, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.
Genome Biol. 2007 Apr 9;8(4):R52
Martchenko M, Levitin A, Whiteway M. Transcriptional activation domains of the Candida albicans Gcn4p and Gal4p homologs.
Eukaryot Cell. 2007 Feb;6(2):291-301
Braun BR, van Het Hoog M, d’Enfert C, Martchenko M, Dungan J, Kuo A, Inglis DO, Uhl MA, Hogues H, Berriman M, Lorenz M, Levitin A, Oberholzer U, Bachewich C, Harcus D, Marcil A, Dignard D, Iouk T, Zito R, Frangeul L, Tekaia F, Rutherford K, Wang E, Munro CA, Bates S, Gow NA, Hoyer LL, Köhler G, Morschhäuser J, Newport G, Znaidi S, Raymond M, Turcotte B, Sherlock G, Costanzo M, Ihmels J, Berman J, Sanglard D, Agabian N, Mitchell AP, Johnson AD, Whiteway M, Nantel A. A human-curated annotation of the Candida albicans genome.
PLoS Genet. 2005 Jul;1(1):36-57
Martchenko M, Alarco AM, Harcus D, and Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene.
Mol Biol Cell. 2004 Feb;15(2):456-67
“Methods and Compositions for Preventing and Treating an Anthrax Toxin Mediated Condition in a Subject”, Mikhail Martchenko, Sun-Young Jeong, and Stanley N. Cohen. U.S. Provisional Application Serial No. 61/523,693. Filing date August 15, 2011.
Commencement: May 15, 2021
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