Dr. Sumbria received her PhD in Pharmaceutical Sciences from the Texas Tech University Health Sciences Center (TTUHSC) in 2010. At TTUHSC, her research centered on the development of intracerebral microdialysis as an experimental tool to study changes in the blood-brain barrier (BBB) permeability in ischemic stroke.
Dr. Sumbria completed her postdoctoral training at the Department of Medicine, blood-brain barrier laboratory at the University of California, Los Angeles and the Department of Neurology at the University of California, Irvine from 2011-2014. During her postdoctoral research at UCLA, Dr. Sumbria focused on the problem of the BBB bottleneck in CNS drug delivery. Particularly, her research focused on the use of receptor-mediated transcytosis for non-invasive delivery of biologics and other large molecular weight therapeutics across the BBB, and studying their pharmacologic effects in different experimental models of CNS disorders. At UCI, the focus of her research was studying the role of cerebral microbleeds in cerebrovascular diseases like stroke.
Besides research, Dr. Sumbria has been extensively involved in teaching and mentoring laboratory research personnel’s and graduate students. Dr. Sumbria received her Ph.D. in Pharmaceutical Sciences from the School of Pharmacy at Texas Tech University Health Sciences Center in Amarillo, Texas and a Bachelor of Technology (B.Tech) in Pharmaceuticals & Fine Chemicals from the Institute of Chemical Technology in Mumbai, India.
Yang, F., Sumbria, R., Xue, D., Yu, C., He, D., Liu, S., Paganini-Hill, A., Fisher, M. (2014): Effects of PDE4 Pathway Inhibition in Rat Experimental Stroke. J. Pharm. Pharm. Sci., 2014;17(3):362-70.
Liu, S., Grigoryan, M., Vasilevko, V., Sumbria, R., Paganini-Hill, A., Cribbs, D., Fisher, M. (2014): Comparative Analysis of H&E and Prussian Blue Staining in a Mouse Model of Cerebral Microbleeds. J. Histochem. Cytochem., Epub ahead of print. PMID: 25063000.
Sumbria, R., Lu, J.Z., Hui, E.K.-W., Boado, R.J., Pardridge, W.M. (2013): Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bi-Specific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide. Mol Pharm., Epub ahead of print. PMID: 23924247.
Boado, R.J., Lu, J.Z., Hui, E.K.-W., Sumbria, R., Pardridge, W.M. (2013): Blood-Brain Barrier Molecular Trojan Horse Enables Brain Imaging of Radioiodinated Recombinant Protein in the Rhesus Monkey. Bioconjug. Chem., Epub ahead of print. PMID: 24059813.
Sumbria, R., Boado, R.J., Pardridge, W.M. (2013): Combination Stroke Therapy in the Mouse with Blood-Brain Barrier Penetrating IgG-GDNF and IgG-TNF Decoy Receptor Fusion Proteins. Brain Res., Epub ahead of print. PMID: 23428543.
Sumbria, R., Zhou, Q.-H., Lu, J.Z., Hui, E.K.-W., Boado, R.J., Pardridge, W.M. (2013): Pharmacokinetics and Brain Uptake of an IgG-TNF Decoy Receptor Fusion Protein Following Intravenous, Intraperitoneal and Subcutaneous Administration in the Mouse.Mol Pharm., Epub ahead of print. PMID: 23410508.
Boado, R.J., Lu, J.Z., Hui, E.K.-W., Sumbria, R., Pardridge, W.M. (2012): Pharmacokinetics and Brain Uptake in the Rhesus Monkey of Fusion Protein of Arylsulfatase A and a Monoclonal Antibody Against the Human Insulin Receptor. Biotechnol Bioeng., Epub ahead of print. PMID: 23192358.
Sumbria, R., Boado, R.J., Pardridge, W.M. (2012): Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein. J. Cereb. Blood Flow Metab., 32(10):1933-8. PMID: 22714051.
Sumbria, R., Boado, R.J., Pardridge, W.M. (2012): Imaging Amyloid Plaque in Alzheimer’s Disease Brain with a Biotinylated Aβ Peptide Radiopharmaceutical Conjugated to an IgG-Avidin Fusion Protein.Bioconjug. Chem., Epub ahead of print. PMID: 22624578.
Mdzinarishvili, A., Sumbria, R., Lang, D., Klein,J. (2012): Ginkgo Extract Egb761 Confers Neuroprotection by Reduction of Glutamate Release in Ischemic Brain. J. Pharm. Pharm. Sci.,15(1):94-102. PMID: 22365091.
Lang, D., Kiewert, C., Mdzinarishvili, A., Schwarzkopf. T.M., Sumbria, R., Hartmann, J., Klein, J. (2011): Bilobalide, a Neuroprotectant that Reduces Ischemia-Induced Glutamate Release In Vivo. Brain Res., 1425:155-63. PMID: 22032877.
Zhou, Q.-H., Sumbria, R., Hui, E.K.-W., Lu, J.Z., Boado, R.J., and Pardridge, W.M. (2011): Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor. J. Pharmacol. Exp. Ther., 339: 618-623. PMID: 21831964.