Saurav Datta, PhD

Saurav Datta joined KGI as an Assistant Professor of the Amgen Bioprocessing Center in the Henry E. Riggs School of Applied Life Sciences in January 2020. Prior to that, he served as an Assistant Professor at the Department of Biotechnology, Indian Institute of Technology Roorkee (IIT Roorkee), India from 2014-2019. He also worked as a Chemical Engineer (2011-2013) and as a Postdoctoral Fellow (2008-2010) at Energy Systems Division, Argonne National Laboratory.

He has major research contributions in the areas of bioprocessing (bioseparation, biocatalysis and bio-based product formation), water treatment, and CO₂ capture. His current research interests encompass downstream processing of biopharmaceuticals, bioreaction engineering and bioinspired materials.

Datta earned his PhD from the Department of Chemical and Materials Engineering, University of Kentucky. He obtained master’s and bachelor’s degrees in Chemical Engineering from Indian Institute of Technology Kanpur (IIT Kanpur) and University of Calcutta, India, respectively.

1. A. Verma, A. K. Sharma, P. Chakraborty, A. Agarwal, P. P. Sarangi, S. Datta^*, Kiran Ambatipudi^*, Selective enrichment of milk fat globules using functionalized polyvinylidene fluoride membrane, Preparative Biochem. Biotechnol., 50 (2020) 18–27
2. D. Somayajula, A. Agarwal, A. K. Sharma, A. E. Pall, S. Datta^*, G. Ghosh*, In Situ Synthesis of Silver Nanoparticles within Hydrogel-conjugated Membrane for Enhanced Anti-Bacterial Properties, ACS Appl. BioMater., 2 (2019) 665–674
3. B. Singh, P. Kumar, A. Maheshwari, Anjlika, S. Datta^*, Degradation of fermentation inhibitors from lignocellulosic hydrolysate liquor using immobilized Bordetella sp. BTIITR, Chem. Eng. J., 361 (2019) 1152-1160
4. A. Kumari, L. Rekhie, S. Datta^*, Reversibly attached phospholipid bilayer functionalized membrane pores, Langmuir, 34 (2018) 14395-14401
5. A. Kumari, S. Datta^*, Phospholipid bilayer functionalized membrane pores for enhanced efficiency of immobilized glucose oxidase enzyme, J. Mem. Sci., 539 (2017) 43-51
6. B. Singh, A. Verma, Pooja, P. K. Mandal, S. Datta^*, A Biotechnological Approach for Degradation of Inhibitory Compounds Present in Lignocellulosic Biomass Hydrolysate Liquor Using Bordetella sp. BTIITR, Chem. Eng. J., 328 (2017) 519-526
7. S. Bharatiy, M. Hazra, M. Paul, S. Mohapatra, D. Samantaray, R. C. Dubey, S. Sanyal, S. Datta^*, S. Hazra^*, In silico designing of an industrially sustainable carbonic anhydrase using Molecular Dynamics Simulation, ACS Omega, 1 (2016) 1081-103
8. S. Datta, Michael P. Henry, Yupo J. Lin, Seth W. Snyder et al., Electrochemical CO₂ capture using resin-wafer electrodeionization (RW-EDI), Ind. Eng. Chem. Res., 52 (2013), 15177–15186
9. S. Datta, Seth W. Snyder, Akash A. Moradia, Michael P. Henry, Cindy S. Millard, Yupo J. Lin, Removal of acidic impurities from corn stover hydrolysate liquor by resin-wafer electrodeionization (RW-EDI), Ind. Eng. Chem. Res., 52 (2013), 13777–13784
10. S. R. Lewis, S Datta, M. Gui, F. E. Huggins, S. Daunert, L. G. Bachas, D. Bhattacharyya, Reactive Nanostructured Membranes for Water Purification, Proceedings of The National Academy of Sciences (PNAS) USA, 108 (2011), 8577-8582
11. R. N. Gurram, S. Datta, Yupo J. Lin, Seth W. Snyder, and Todd J. Menkhaus, Removal of Enzymatic and Fermentation Inhibitory Compounds from Biomass Slurries for Enhanced Biorefinery Process Efficiencies, Bioresource Technology, 102 (2011), 7850–7859
12. S. Datta, B. D. Bals, Yupo J. Lin, M. C. Negri, R. Datta, L. Pasieta, Sabeen F. Ahmad, Akash A. Moradia, B. E. Dale, Seth W. Snyder, An Attempt towards Simultaneous Biobased Solvent Based Extraction of Proteins and Enzymatic Saccharification of Cellulosic Materials from Distiller’s Grains and Solubles, Bioresource Technology, 101 (2010), 5444-5448
13. S. Datta, C. Cecil, D. Bhattacharyya, Functionalized Membranes by Layer-By-Layer Assembly of Polyelectrolytes and In Situ Polymerization of Acrylic Acid for Applications in Enzymatic Catalysis, Ind. Eng. Chem. Res. (Centennial Issue), 47 (2008), 4586–4597
14. S. Datta, Philip D. Ray, A. Nath, D. Bhattacharyya, Selective separation of HIV-Tat protein using functionalized stacked microfiltration membranes: Enhancement of flux and recovery of protein, Separation Science and Technology 42 (2007), 2451-2471
15. S. Datta, Philip D. Ray, A. Nath, D. Bhattacharyya, Recognition based separation of HIV-Tat protein using avidin-biotin interaction in modified microfiltration membranes, Journal of Membrane Science 280 (2006), 298-310
16. S. Datta, P. K. Bhattacharya, N. Verma, Removal of aniline from aqueous solution in a MFR using emulsion liquid membrane, Journal of Membrane Science 226 (2003), 185-201

Book Chapters

1. G. Ghosh, S. Datta, A. Kumari, Hydrogel-based biosensors: fundamentals and applications, in Nanobiosensors for personalized and onsite biomedical diagnosis, Institution of Engineering and Technology, 2016
2. B. Singh, A. Kumari, S. Datta, Separations technologies for biobased product formation – opportunities and challenges, in Commercializing biobased products, Royal Society of Chemistry, 2015

S. Datta, Y. P. Lin, Seth W. Snyder, Current and emerging separation technologies in biorefining, in Advances in biorefineries, Woodhead Publishing, 2015

We leverage fundamental principles of Chemical Engineering, Chemistry, and Biotechnology and aim to develop advanced bioprocesses with higher efficiency, lower cost, and feasibility for scale-up. Research activities in three major areas are outlined below.

Downstream processing: Development of membrane and chromatographic methods for advanced bioprocessing in gene/cell therapy, mAb production and viral clearance.

Bioreactions engineering: Study of reaction kinetics and reactor theories for next-generation bioreactors, such as hollow fiber perfusion bioreactor or continuous packed-bed reactor.

Bioinspired materials: Mimic mother nature for advanced bioprocessing, such as cell-free synthesis using immobilized enzyme cascades.

1. S. Datta, Ayushi Agarwal, Anju Kumari, A virus removal/recovery membrane and its preparation method, Indian Patent application number 201811022826, 2018
2. K. Ambatipudi, S. Datta, A. Verma, Functionalized membrane-based process for selective isolation and enrichment of milk fat globules (MFGs), Indian Patent application number 201811013231, 2018
3. Y. J. Lin, S. W. Snyder, M. P. Henry, S. Datta, Internal gas and liquid distributor for electrodeionization device, US Patent 9,339,764, 2016
4. D. Bhattacharyya, S. R. Lewis, S. Datta, Chemical processing cell with nanostructured membranes, US Patent 9,174,173, 2015
5. Y. J. Lin, S. W. Snyder, S. Datta, M. Trachtenberg, R. Cowen, Carbon dioxide capture using resin-wafer electrodeionization, U.S. Patent 8506784, 2013