Year: 2018-19

Company: Coherus BioSciences

Liaison(s): Russ Grove, Robin Modi

Coherus BioSciences is a biotechnology company focused on the development of biosimilars. Currently, Coherus BioSciences has one approved product, UDENYCA™ (pegfilgrastim-cbqv), a biosimilar to Neulasta® (pegfilgrastim), and several others are in development.

The objective of this Team Master’s Project was to develop a next generation fed-batch process for one of Coherus’s biologics. This work was carried out by screening several feeding strategies in shake flasks and scaling up promising strategies in benchtop bioreactors. The results of this project will inform the future efforts of Coherus’s process development team.