Year: 2022-23

Company: Boehringer Ingelheim

Liaison(s): Benjamin Ko

The objective of this project is to enhance our understanding of mixing in downstream hold tanks and associated small-scale models through computational fluid dynamics (CFD). These portable and fixed hold tanks are used for mixing of pools at various adjustment steps—most notably low pH viral inactivation—and pool homogeneity is critical to a successful process. Computational models help us to better understand and visualize mixing dynamics within these tanks and also enable us to evaluate the utility of our current lab-scale model. This project will build upon previous work conducted in a 2021-22 TMP. Students will first use established CFD protocols to confirm previous study results and further characterize mixing behaviors within the downstream hold tanks studied. Secondly, additional downstream hold tank families will be modeled and characterized. Finally, students will use CFD to assess the validity of an existing scale-down model as compared with the corresponding at-scale tank and explore alternative scale-down models as appropriate.