Year: 2006-07

Company: Amgen

Liaison(s): Bruce Eu, Bob Platz

This joint Keck Graduate Institute-Harvey Mudd College project was continued from last year. The main goal was to evaluate the switch from glass to plastic pre-filled syringes. To support the assessment, analytical biochemistry experimental methods were developed to minimize oxygen permeation in plastic syringes. The team also tested various secondary packaging and oxygen absorber systems. The experimental results were strengthened by developing and refining a mathematical model of oxygen permeation through syringe and secondary packages. The technical evaluation was complemented by market research and financial models. Patent research to investigate licensing opportunities and potential infringement are completed.