Year: 2017-18

Company: Boehringer Ingelheim

Liaison(s): Garima Chaudhary, Marcella Yu, Samet Yildirim

Boehringer Ingelheim (BI) GmbH is a leading biopharmaceutical manufacturer with a product line ranging from small molecule drugs and therapeutic enzymes, to biologics and biosimilars. Within biopharmaceutical manufacturing, Boehringer Ingelheim offers multiple service options as a Contract Manufacturing Organization (CMO), from cell line development, to process development and commercial manufacturing. In order to assist their customers in these endeavors, Boehringer Ingelheim is devoted to create value through innovation in biomanufacturing.

The goal of this project was to characterize Boehringer Ingelheim’s three scales of bioreactors: Laboratory scale, Pilot Scale, and Manufacturing Scale using computational fluid dynamics. Computational fluid dynamics is an in silico technique to characterize process equipment used in the biopharmaceutical industry. Establishing operating boundaries, understanding complex fluid flow and mass transfer, and evaluating scaling performance is essential for tech transfer between sites and customers. The TMP team simulated single-phase fluid flow and gas transfer for the three scales of bioreactors based on given bioreactor geometries and operating conditions using CFD
Boehringer Ingelheim (BI) GmbH is a leading biopharmaceutical manufacturer with a product line ranging from small molecule drugs and therapeutic enzymes, to biologics and biosimilars. Within biopharmaceutical manufacturing, Boehringer Ingelheim offers multiple service options as a Contract Manufacturing Organization (CMO), from cell line development, to process development and commercial manufacturing. In order to assist their customers in these endeavors, Boehringer Ingelheim is devoted to create value through innovation in biomanufacturing.

The goal of this project was to characterize Boehringer Ingelheim’s three scales of bioreactors: Laboratory scale, Pilot Scale, and Manufacturing Scale using computational fluid dynamics. Computational fluid dynamics is an in silico technique to characterize process equipment used in the biopharmaceutical industry. Establishing operating boundaries, understanding complex fluid flow and mass transfer, and evaluating scaling performance is essential for tech transfer between sites and customers. The TMP team simulated single-phase fluid flow and gas transfer for the three scales of bioreactors based on given bioreactor geometries and operating conditions using CFD