Gargi Ghosh, PhD, joined the Amgen Bioprocessing Center in the Henry E. Riggs School of Applied Life Sciences at Keck Graduate Institute (KGI) as an Associate Professor in August 2022. Before that, Ghosh was a faculty in the Mechanical Engineering Department at the University of Michigan-Dearborn. Before that, Ghosh worked as a Postdoctoral Fellow with Professor Sean Palecek at the University of Wisconsin, Madison, and Professor Stephen Kron at the University of Chicago. Earlier, Ghosh earned her PhD from the Department of Chemical and Materials Engineering at the University of Kentucky. Ghosh obtained master’s and bachelor’s degrees in Chemical Engineering from the Indian Institute of Technology Kanpur and the University of Calcutta, India, respectively. Her research interests focus on stem cell therapy and regenerative medicine.
G. Ghosh, S. Datta, A. Kumari, Hydrogel-based biosensors: fundamentals and applications, in Nanobiosensors for personalized and onsite biomedical diagnosis, Institution of Engineering and Technology, 2016
We integrate biomaterials, stem cell engineering, and cellular and molecular biology towards breaking the bottlenecks in stem cell therapies, especially biomanufacturing mesenchymal stem cell (MSC)-derived exosomes for clinical applications, deciphering stem cell-material interaction towards expansion and delivery of stem cells, and regulating MSC therapeutic activity for diabetic wound healing. Research activities are outlined below.
Biomanufacturing stem-cell derived exosomes: MSC-derived exosomes possess regenerative and immunomodulatory properties; despite their therapeutic potential FDA is yet to approve any exosome-based therapy. This is primarily due to the inherent limitations including low productivity and lack of standard quality control. We are involved in optimizing the exosome production via manipulation of cell culture conditions including the passage number, differentiation status, and culture surface compositions.
Hybrid hydrogels for stem cell expansion and delivery: The challenges associated with in vitro expansion of MSC to therapeutically relevant number as well as the poor survival rate of implanted MSCs limit clinical translation of cell-based therapies for various diseases and injuries. The goal of this project to address these clinical problems via materials-based strategy, namely screening cell-matrix and cell-cell interactions that prolong the self-renewal and regenerative capacity of MSCs and promote the survival of encapsulated MSCs.
Regulating MSC-secretome for diabetic wound healing: Healing of wounds involve a cascade of events including inflammation, re-epithelialization, angiogenesis, and tissue formation. Elderly patients as well as patients suffering from systemic diseases often develop non-healing/chronic wounds. The goal of this project is to investigate the combinatorial effect of ECM and MSC-secretome on repair of hard-to-heal wounds.
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