This is the capstone project. The students will work in teams to design a complete biomanufacturing plant capable of producing commercial quantities of an API or DP. Each team will work on a separate and specific project leading to a process. Typical examples include manufacturing of insulin, human growth hormone, tissue plasminogen activator, monoclonal antibodies for caners, and autoimmune diseases. Students will evaluate potential commercial opportunities and manufacturing options, selecting the expression system, designing the bioreactor, harvesting and purification sequence of operations. A detailed literature survey will be included to understand the best industry practices. Team discussion and consultation with subject matter experts within KGI and with external companies will then be followed leading to specification of the purity profile for the product. This is then followed by preparation of detailed engineering flow sheet that includes each unit operation. Selection and sizing of each equipment for each unit operation will then be carried to meet a specified annual demand for the product. Finally, an economic evaluation of the process will be carried out to evaluate the cost of good and potential pricing of the product. The final design will be evaluated and interpreted using available simulation and modelling techniques. A group report and individual report will be presented by each student in the team.(MEB 408)
MEng program students only
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