PhD Literature Mastery Presentation – Ana Mena Amores, PhD Student – “Development of a Transient AAV Manufacturing Platform”

Please join us for PhD Student, Ana Mena Amores’ PhD Literature Mastery Presentation.

Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for many diseases like retinal disorders and spinal muscular atrophy. Recent developments on the production of AAV capsids, vector design optimization, and cell culture techniques have contributed substantially to the growth of gene therapy in biotech. Due to this, there are currently more preclinical and clinical trials that can succeed in AAV-mediated gene replacement, silencing, and editing. With two AAV-based therapeutics approvals in Europe and the United States, the AAV platforms are gaining popularity as an ideal therapeutic vector due to its scalability and unique advantages in human immune responses. One of the most used cell lines for AAV production are HEK293 cells. Despite decades of research, there are not many studies that focus on the manufacturing process or its optimization. Only 30% of AAV produced by cells contain the therapeutic element causing low yields. Therefore, many resources are put into the purification stage of the process to offset losses. The development of a new high-producing platform from the early stages itself can provide solutions to some of the current challenges in the industry.

Date:  Friday, November 18, 2022

Time:  12:00 – 1:00 p.m.

Location:  121 Bldg. – 1111 Classroom and Via Zoom (See Outlook invite for Zoom Link)